Arsenal and Chelsea will both rest a number of their first-team regulars against Braga and MSK Zilina respectively in the latest round of Champions League fixtures
The Gunners will leave out Robin van Persie and Andrey Arshavin for the trip to Portugal to face Braga, which defender Gael Clichy also misses because of a back problem.
England left-back Kieran Gibbs looks set to start, while Denmark striker Nicklas Bendtner returns to contention after his groin problems.
Goalkeeper Manuel Almunia (elbow), centre-half Thomas Vermaelen (Achilles) and midfielder Abou Diaby (ankle) remain out, while Aaron Ramsey continues his rehabilitation following a broken leg.
Blues goalkeeper Petr Cech and striker Nicolas Anelka will be missing when MSK Zilina visit Stamford Bridge, while coach Carlo Ancelotti gives a first-ever start to teenage midfielder Josh McEachran.
The Blues are without injured John Terry (thigh), Frank Lampard (tendon), Yury Zhirkov (calf), John Mikel Obi (knee), Alex (knee) and Yossi Benayoun (Achilles).
Jeffrey Bruma will play alongside Branislav Ivanovic at the heart of the defence.